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Medically reviewed by Dr. Laura Henderson- Dr. Laura Henderson, MD Board-Certified Internal Medicine Physician,

Key takeaways

Xanax acts fastest (15 to 30 minutes) but has the shortest duration, making it ideal for panic attacks.

Klonopin provides the longest-lasting effects (6 to 12 hours) with moderate onset time for generalized anxiety.

Ativan offers balanced onset and duration, and is commonly used in hospital settings for acute anxiety.

Valium has the longest half-life (20 to 70 hours) and the strongest muscle relaxant properties of the four.

A plain-language look at GABA-A receptors, why sleep onset shortens in about twenty minutes, and why the lowest effective dose matters more than the strongest one

Any Questions About benzodiazepines?

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